Single-Dose Nirsevimab Prevents RSV Infection

• 2021

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• Shabir Madhi; Eric Simões
PMID: 33342497DOI: https://doi.org/10.1016/j.jpeds.2020.10.066

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This article commentary discusses a study on nirsevimab, a single-dose treatment that helps prevent RSV infections in preterm infants. Conducted across 164 sites in 23 countries, the trial showed that nirsevimab reduced RSV-related lung infections and hospitalizations. It was more effective than placebo, with significant reductions in risk and fewer needed treatments to see benefits. The study highlights the lack of licensed vaccines for RSV and suggests nirsevimab as a promising option. However, concerns about viral mutations affecting its effectiveness and issues like cost may limit access for children in low-income areas.

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Tags

Focus Area: Infectious Disease

Keywords: Infant; Infant, Newborn; Respiratory Syncytial Virus Infections; Respiratory Syncytial Viruses; Respiratory Tract Infections; Antibodies, Monoclonal, Humanized

Emergency Management Stage: Preparedness (Prevention / Protection)

Audience: Physicians

Format: Journal Article

Media Type: Website

Institutions: University of the Witwatersrand; University of Colorado

Institution Types: Academic; Academic

Language: English

Bundles: Nirsevimab Library

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Single-Dose Nirsevimab Prevents RSV Infection 2021 · University of the Witwatersrand, University of Colorado Single-Dose Nirsevimab for Prevention of RSV in Preterm Infants 2020 · AstraZeneca, State University of New York - Upstate Medical University, University of the Witwatersrand, University of Colorado, Le Bonheur Children's Hospital, Città della Salute e della Scienza Efficacy of Nirsevimab Against Respiratory Syncytial Virus Lower Respiratory Tract Infections in Preterm and Term Infants, and Pharmacokinetic Extrapolation to Infants With Congenital Heart Disease and Chronic Lung Disease: A Pooled Analysis of Randomised Controlled Trials 2023 · Children's Hospital Colorado, University of the Witwatersrand, Northwestern University, Dr. Georgi Stranski University Hospital, Quironsalud Madrid University Hospital, State University of New York - Upstate Medical University

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