RSV Prevention Within Reach for Older Infants and Toddlers: The Role of Active Immunization

• 2024

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• Asuncion Mejia; Octavio Ramilo
PMID: 38995087DOI: https://dx.doi.org/10.1093/jpids/piae049

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This article reviews efforts to prevent RSV in older infants and toddlers through active immunization. It highlights the global impact of RSV, especially in young children, and reviews vaccines and monoclonal antibodies being tested for prevention. The focus is on passive protection during early months and active immunization later with live attenuated, protein-based, or mRNA vaccines. Recent advancements include structure-based vaccine design targeting the F protein of RSV. The article emphasizes ongoing research to develop effective strategies for protecting vulnerable children from severe respiratory infections caused by RSV.

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Tags

Focus Area: Infectious Disease

Audience: Physicians

Emergency Management Stage: Preparedness (Prevention / Protection)

Collection: Nirsevimab Library

Keywords: Antibodies, Monoclonal; Child, Preschool; Immunization, Passive; Infant; Infant, Newborn; Respiratory Syncytial Virus Infections; Vaccines; Vaccines, Attenuated; Respiratory Syncytial Virus, Human; Respiratory Syncytial Virus Vaccines

Institutions: St. Jude Children's Research Hospital; University of Tennessee

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