Infants Receiving a Single Dose of Nirsevimab to Prevent RSV Do Not Have Evidence of Enhanced Disease in Their Second RSV Season

• 2024

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• Ron Dagan; Laura Hammitt; Beatriz Nuñez; Manuel Cots; Miroslava Bosheva; Shabir Madhi
PMID: 38219024DOI: https://doi.org/10.1093/jpids/piad113

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This article describes a study on nirsevimab, a monoclonal antibody used to prevent RSV in infants. It shows that infants who received one dose of nirsevimab did not have worse RSV disease in their second season compared to those given a placebo. The study involved over 3,000 children and found no evidence of increased disease severity or enhanced infection due to the treatment. Nirsevimab was effective and safe for preventing serious lower respiratory tract infections caused by RSV without shifting the burden of illness to the second year of life.

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Tags

Focus Area: Infectious Disease

Audience: Physicians

Emergency Management Stage: Preparedness (Prevention / Protection)

Bundle: Nirsevimab Library

Keywords: Immunization, Passive; Infant; Respiratory Syncytial Virus Infections; Respiratory Tract Infections; Respiratory Syncytial Virus, Human; Clinical Trials, Phase III as Topic; Antibodies, Monoclonal, Humanized

Institutions: Ben-Gurion University of the Negev; Johns Hopkins University; AstraZeneca; Quirónsalud Málaga Hospital; Medical University of Plovdiv; University of the Witwatersrand

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