Nirsevimab for Prevention of Hospitalizations Due to RSV in Infants

• 2023

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• Simon Drysdale; Katrina Cathie; Florence Flamein; Markus Knuf; Andrea Collins; Helen Hill
PMID: 38157500DOI: https://doi.org/10.1056/NEJMoa2309189

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This article discusses a study on nirsevimab, a monoclonal antibody used to prevent hospitalizations due to RSV in infants. It was tested on 8,058 infants in France, Germany, and the UK. The results showed that nirsevimab reduced RSV-related hospitalizations by 83.2% compared to standard care. It also decreased severe cases needing oxygen support by 75.7%. The study found no major safety concerns with nirsevimab use and suggests it could help reduce the burden of RSV hospitalizations among infants during their first season of exposure to the virus.

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Tags

Focus Area: Infectious Disease

Audience: Physicians

Emergency Management Stage: Preparedness (Prevention / Protection)

Bundles: Nirsevimab Library

Keywords: France; Germany; Hospitalization; Infant; Respiratory Syncytial Virus Infections; Respiratory Tract Infections; United Kingdom; Respiratory Syncytial Virus, Human; Antibodies, Monoclonal, Humanized

Institutions: St. George's University Hospitals NHS Foundation Trust; University Hospital Southampton NHS Foundation Trust; Liverpool University Hospitals Foundation NHS Trust; Sanofi; Université Paris-Saclay; Assistance Publique - Hôpitaux de Paris (AP-HP)

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