Nirsevimab and Hospitalization for RSV Bronchiolitis

• 2024

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• Zein Assad; Anne-Sophie Romain; Camille Aupiais; Mickaël Shum; Cécile Schrimpf; Mathie Lorrot
PMID: 38986058DOI: https://dx.doi.org/10.1056/NEJMoa2314885

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About

This study looks at how well nirsevimab, a monoclonal antibody, works in preventing hospitalizations for RSV bronchiolitis in infants under 12 months. Conducted across multiple centers, it compares infants hospitalized with RSV to those visiting hospitals for other reasons. Results show that nirsevimab reduces the risk of hospitalization by 83% and is also effective against severe cases needing critical care or ventilatory support. The findings suggest that nirsevimab can significantly lower the chances of serious RSV-related illness in young children.

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Tags

Focus Area: Infectious Disease

Audience: Physicians

Emergency Management Stage: Preparedness (Prevention / Protection)

Bundles: Nirsevimab Library

Keywords: Antiviral Agents; Bronchiolitis; Hospitalization; Infant; Infant, Newborn; Respiratory Syncytial Virus Infections; Respiratory Syncytial Viruses; Antibodies, Monoclonal, Humanized

Institutions: Paris Cité University; Sorbonne University; INSERM Unité

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